Ген

Siddkhartkha Mukerdzhi rasskazyvaet istorii͡u genetiki ot pervykh dogadok Aristoteli͡a o nasledstvennosti, peredai͡ushcheĭsi͡a cherez krovʹ, do oshelomli͡ai͡ushchikh otkrytiĭ, sovershennykh za poslednie dvesti let, tolchkom k kotorym stali ėksperimenty monakha Gregora Ioganna Mendeli͡a. Kniga takzhe posvi͡ashchaet chitateli͡a v sovremennye issledovanii͡a v oblasti biotekhnologiĭ, gennoĭ terapii i genomiki.Mukerdzhi ne boitsi͡a zatragivatʹ slozhnye voprosy. Katastroficheskie programmy evgeniki nachala 20-go veka, tragicheski neudachnye ispytanii͡a rannikh metodov gennoĭ terapii i samo nashe predstavlenie o poni͡atii "boleznʹ" - ko vsem ėtim temam avtor podkhodit s bolʹshim taktom i sostradaniem.Povestvovanie pronizyvai͡ut vospominanii͡a samogo Mukerdzhi i rasskazy o tom, kak nasledstvennye zabolevanii͡a zatronuli ego sobstvennui͡u semʹi͡u. Avtor podcherkivaet neveroi͡atno slozhnye sochetanii͡a sluchai͡a, okruzhai͡ushcheĭ sredy i kombinat͡siĭ genov, opredeli͡ai͡ushchikh nashu vospriimchivostʹ k zabolevanii͡am, i preduprezhdaet utopicheskie ozhidanii͡a i nadezhdy na panat͡sei͡u. Uchityvai͡a nashi rastushchie vozmozhnosti korrektirovanii͡a geneticheskogo koda, Mukerdzhi prizyvaet k debatam ob ėticheskikh ogranichenii͡akh, neobkhodimykh dli͡a budushchego vmeshatelʹstva v gennyĭ kod zhivogo organizma.

Siddhartha Mukherjee tells the story of genetics from Aristotle's first guesses about heredity transmitted through blood to the stunning discoveries made over the past two hundred years, which were triggered by the experiments of monk Gregor Johann Mendel. The book also dedicates the reader to modern research in the field of biotechnology, gene therapy and genomics.Mukherjee is not afraid to touch on difficult issues. The disastrous eugenics programs of the early 20th century, the tragically unsuccessful trials of early gene therapy methods and our very idea of the concept of “disease” - the author approaches all these topics with great tact and compassion.The narrative is permeated by Mukherjee's own memories and stories about how hereditary diseases affected his own family. The author emphasizes the incredibly complex combinations of chance, environment and combinations of genes that determine our susceptibility to diseases, and warns utopian expectations and hopes for a panacea. Given our growing opportunities to correct the genetic code, Mukherjee calls for a debate about the ethical constraints necessary for future intervention in the genetic code of a living organism.